Scott B Snapper Selected Research

Wiskott-Aldrich Syndrome Protein

11/2021	Utilizing a reductionist model to study host-microbe interactions in intestinal inflammation.
1/2021	Constitutive activation of WASp leads to abnormal cytotoxic cells with increased granzyme B and degranulation response to target cells.
1/2018	WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis.
1/2018	Constitutive activation of WASp in X-linked neutropenia renders neutrophils hyperactive.
9/2013	Colitis and colon cancer in WASP-deficient mice require helicobacter species.
9/2012	Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice.
2/2011	Intestinal alkaline phosphatase has beneficial effects in mouse models of chronic colitis.
6/2010	Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes.
2/2010	Neural Wiskott-Aldrich syndrome protein modulates Wnt signaling and is required for hair follicle cycling in mice.
10/2007	Lymphocyte-dependent and Th2 cytokine-associated colitis in mice deficient in Wiskott-Aldrich syndrome protein.

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Scott B Snapper Research Topics

Disease

25	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 06/2022 - 06/2004
21	Colitis 10/2022 - 03/2003
20	Inflammation (Inflammations) 10/2022 - 06/2004
7	Wiskott-Aldrich Syndrome 10/2016 - 03/2003
6	Crohn Disease (Crohn's Disease) 01/2022 - 01/2012
4	Infections 01/2020 - 12/2008
3	Neutropenia 01/2021 - 06/2010
3	Enterocolitis 04/2014 - 11/2009
2	Virus Diseases (Viral Diseases) 01/2020 - 12/2003
2	Diarrhea 01/2019 - 01/2019
2	Gastrointestinal Diseases (Functional Gastrointestinal Disorders) 01/2019 - 01/2017
2	Cicatrix (Scar) 10/2011 - 01/2004
1	Growth Disorders 09/2022
1	Rare Diseases (Rare Disease) 06/2022
1	Sensorineural Hearing Loss 11/2021
1	Hereditary alpha-tryptasemia syndrome 01/2021
1	Intestinal Atresia 10/2020
1	Lung Injury 01/2020
1	Ulcerative Colitis 07/2019
1	Failure to Thrive 01/2019
1	2 X-Linked Lymphoproliferative Syndrome 01/2019
1	Bacterial Infections (Bacterial Infection) 01/2018
1	Gastroesophageal Reflux (GERD) 01/2018
1	Hypersensitivity (Allergy) 01/2018
1	Eosinophilic Esophagitis 01/2018
1	Autosomal Recessive 3 Severe Congenital Neutropenia 01/2018
1	Thrombosis (Thrombus) 01/2017
1	Protein-Losing Enteropathies (Protein-Losing Enteropathy) 01/2017
1	B-Cell Lymphoma (Lymphoma, B Cell) 01/2016
1	X-Linked Syndrome Enteropathy Polyendocrinopathy Immune Dysregulation 06/2015
1	Renal Insufficiency (Renal Failure) 09/2014

Drug/Important Bio-Agent (IBA)

14	Wiskott-Aldrich Syndrome ProteinIBA 11/2021 - 12/2003
12	Interleukin-10 (Interleukin 10)IBA 10/2022 - 09/2012
12	Proteins (Proteins, Gene)FDA Link 01/2022 - 07/2003
7	Interleukin-10 ReceptorsIBA 10/2022 - 11/2009
4	CytokinesIBA 10/2009 - 10/2005
3	RNA (Ribonucleic Acid)IBA 06/2022 - 01/2017
3	InterleukinsIBA 01/2018 - 10/2009
3	Interferon-gamma (Interferon, gamma)IBA 12/2016 - 10/2007
3	AutoantibodiesIBA 06/2015 - 06/2004
2	InterferonsIBA 01/2020 - 01/2018
2	Pharmaceutical PreparationsIBA 01/2020 - 07/2014
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2019 - 12/2016
2	Messenger RNA (mRNA)IBA 01/2018 - 01/2017
2	Interleukin-12 (IL 12)IBA 01/2018 - 12/2003
2	Immunoglobulin E (IgE)IBA 01/2018 - 10/2016
2	Clodronic Acid (Clodronate)IBA 01/2017 - 10/2005
2	Oxidoreductases (Dehydrogenase)IBA 09/2015 - 09/2014
2	AntigensIBA 05/2014 - 11/2008
1	Infliximab (Remicade)FDA Link 01/2022
1	Cholecalciferol (Vitamin D3)FDA Link 01/2022
1	GlucocorticoidsIBA 01/2022
1	Qa-SNARE Proteins (Syntaxin)IBA 11/2021
1	Carrier Proteins (Binding Protein)IBA 11/2021
1	Lipocalin-2IBA 11/2021
1	AntibodiesIBA 01/2021
1	Volatile Fatty AcidsIBA 01/2021
1	Immunoglobulin G (IgG)IBA 01/2021
1	SuspensionsIBA 01/2021
1	Tryptases (Tryptase)IBA 01/2021
1	Tight Junction ProteinsIBA 01/2021
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 10/2020
1	Leflunomide (Arava)FDA LinkGeneric 01/2020
1	Anti-Bacterial Agents (Antibiotics)IBA 11/2019
1	Monoclonal AntibodiesIBA 07/2019
1	Muromonab-CD3 (Muromonab CD3)FDA Link 07/2019
1	Interleukin-2 (IL2)IBA 01/2019
1	EnzymesIBA 01/2019
1	Myosin Light Chains (Myosin Essential Light Chain)IBA 01/2019
1	X-Linked Inhibitor of Apoptosis ProteinIBA 01/2019
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2019
1	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 01/2018
1	Phosphotransferases (Kinase)IBA 01/2018
1	sodium sulfate (sodium bisulfate)FDA LinkGeneric 01/2017
1	Complement System Proteins (Complement)IBA 01/2017
1	Dextrans (Dextran)FDA Link 01/2017
1	Small Interfering RNA (siRNA)IBA 01/2017
1	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 12/2016
1	Granzymes (Granzyme)IBA 10/2016
1	AcidsIBA 10/2016
1	AllergensIBA 10/2016
1	Ustekinumab (CNTO 1275)FDA Link 01/2016
1	Antiviral Agents (Antivirals)IBA 01/2016
1	Leukocyte L1 Antigen Complex (Calgranulin)IBA 01/2016
1	C-Reactive ProteinIBA 01/2016
1	NADPH Oxidases (NAD(P)H oxidase)IBA 09/2015
1	Dual OxidasesIBA 09/2015
1	NADP (NADPH)IBA 09/2014
1	Shiga Toxin (Shigella Toxin)IBA 09/2014
1	SaltsIBA 07/2014
1	Dextran SulfateIBA 07/2014
1	ChemokinesIBA 07/2014
1	Chemokine ReceptorsIBA 07/2014
1	LipidsIBA 05/2014
1	microsomal triglyceride transfer proteinIBA 05/2014
1	HSP110 Heat-Shock ProteinsIBA 05/2014

Therapy/Procedure

3	Therapeutics 01/2017 - 02/2011
1	Total Parenteral Nutrition 09/2022
1	Gastrostomy 09/2022
1	Hematopoietic Stem Cell Transplantation 01/2019